Bethanechol; Defination, Mechanism, Indications, Contra Indications, Dosage, Side Effects, Drug Interactions ,Pregnancy Safety

Bethanechol is a slowly hydrolyzing muscarinic agonist with no nicotinic effects. Bethanechol is generally used to increase smooth muscle tone, as in the GI tract following abdominal surgery or in urinary retention in the absence of obstruction. It may cause hypotension, HEART RATE changes, and BRONCHIAL SPASM.

Bethanechol is a synthetic ester structurally and pharmacologically related to acetylcholine. A slowly hydrolyzed muscarinic agonist with no nicotinic effects, bethanechol is generally used to increase smooth muscle tone, as in the GI tract following abdominal surgery or in urinary retention in the absence of obstruction. It may cause hypotension, cardiac rate changes, and bronchial spasms.

Mechanism of Action of Bethanechol

Bethanechol directly stimulates cholinergic receptors in the parasympathetic nervous system while stimulating the ganglia to a lesser extent. Its effects are predominantly muscarinic, inducing little effect on nicotinic receptors and negligible effects on the cardiovascular system.
Bethanechol is a parasympathomimetic (cholinergic) used for the treatment of acute postoperative and postpartum nonobstructive (functional) urinary retention and for neurogenic atony of the urinary bladder with retention. Bethanechol, a cholinergic agent, is a synthetic ester which is structurally and pharmacologically related to acetylcholine. It increases the tone of the detrusor urinae muscle, usually producing a contraction sufficiently strong to initiate micturition and empty the bladder. It stimulates gastric motility, increases gastric tone, and often restores impaired rhythmic peristalsis. Bethanechol chloride is not destroyed by cholinesterase and its effects are more prolonged than those of acetytcholine.

Indications of Bethanechol

Contra Indications of Bethanechol

Dosage of Bethanechol

Strengths: 5 mg; 10 mg; 25 mg; 50 mg; 5 mg/mL

Urinary Retention

  • Initial dose: 5 to 10 mg orally once to obtain minimum effective dose; repeat the same amount at hourly intervals until satisfactory response occurs or a maximum of 50 mg has been given
  • Maintenance dose: 10 to 50 mg orally 3 to 4 times a day

Neurogenic Bladder

  • Initial dose: 5 to 10 mg orally once to obtain minimum effective dose; repeat the same amount at hourly intervals until satisfactory response occurs or a maximum of 50 mg has been given
  • Maintenance dose: 10 to 50 mg orally 3 to 4 times a day

Side Effects of Bethanechol

The most common 

More common

Less common

Drug Interactions of Bethanechol

Bethanechol may interact with following drugs,supplyment & may change the efficacy of drugs

Pregnancy & Lactation of Bethanechol

FDA Pregnancy Category C

Pregnancy

This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Lactation

It is not known if bethanechol chloride passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.The safety and effectiveness of using this medication have not been established for children.

References

  1. PubChem
    Data deposited in or computed by PubChem

    https://pubchem.ncbi.nlm.nih.gov

  2. Anatomical Therapeutic Chemical (ATC) classification

    http://www.genome.jp/kegg-bin/get_htext?br08303.keg

    Risk category of Japanese OTC drugs

    http://www.genome.jp/kegg-bin/get_htext?br08312.keg

  3. International Patent Classification

    http://www.wipo.int/classifications/ipc/

  4. NCBI
    LinkOut is a service that allows one to link directly from NCBI databases to a wide range of information and services beyond NCBI systems.

    https://www.ncbi.nlm.nih.gov/projects/linkout

Bethanechol

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