Butalbital; Uses, Dosage, Side Effects, Interactions, Pregnancy

Butalbital, Butalbital; Uses, Dosage, Side Effects, Interactions, Pregnancy, Rx Harun








User Review


5
(4 votes)


Butalbital is a barbiturate that exerts its effect by mimicking the inhibitory effect of gamma-aminobutyric acid (GABA) by binding to a site, distinct from the benzodiazepine binding site, on the GABA receptor. This leads to an increase in the duration of GABA-mediated opening of chloride channels and enhances the inhibitory effect of GABA. Consequently, its physiologic effects include sedation, hypnosis, reduction of anxiety, and respiratory depression and the drug causes tolerance and dependence.

Butalbital, 5-allyl-5-isobutyl barbituric acid, is a barbiturate with an intermediate duration of action. It has the same chemical formula as talbutal but a different structure. Butalbital is often combined with other medications, such as acetaminophen or aspirin, and is commonly prescribed for the treatment of pain and headache

Butalbital is a barbiturate with an intermediate duration of action. Butalbital is often combined with other medications, such as acetaminophen (paracetamol) or aspirin, and is commonly prescribed for the treatment of pain and headache. Butalbital, 5-allyl-5-isobutyl barbituric acid, is a barbiturate with an intermediate duration of action. It has the same chemical formula as talbutal but a different structure. Butalbital is often combined with other medications, such as acetaminophen or aspirin, and is commonly prescribed for the treatment of pain and headache.

Mechanism of Action of Butalbital

Barbiturates act as nonselective depressants of the central nervous system (CNS), capable of producing all levels of CNS mood alteration from excitation to mild sedation, hypnosis, and deep coma. Insufficiently high therapeutic doses, barbiturates induce anesthesia. Butalbital binds at a distinct binding site associated with a Cl ionopore at the GABAA receptor, increasing the duration of time for which the Cl ionophore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.

You Can Also Like   Pregnancy Category of Diclofenac, Interactions, Warning

Or

The effects of butalbital (30, 100, and 1000 ug/kg) on the number of cells expressing c-fos-like immunoreactivity (c-for-LI), a marker of neuronal activation, within lamina I, IIo of the trigeminal nucleus caudal is and the nucleus of the solitary tract 2 hours after the intracisternal injection of capsaicin (0.1 mL; 15.25 mg/mL) or vehicle in urethane-anesthetized guinea pigs (N = 45) /was examined/. Robust c-fos-LI was observed within nuclei of cells in the trigeminal nucleus caudalis after capsaicin (329 +/- 35). Butalbitaldose-dependently reduced the number of labeled cells to a maximum of 66% (1000 micrograms/kg intraperitoneally [i.p.], P < .01) in lamina I, IIo but not within area postrema, medial reticular nucleus, or the nucleus of the solitary tract. Pretreatment with bicuculline (30 micrograms/kg i.p.) blocked the effect of butalbital, thereby suggesting the importance of the GABAA receptor to activation involved in the transmission of nociceptive information. Our studies suggest the possibility that GABAA receptors might provide an important therapeutic target in a migraine and related headache disorders.

Indications of Butalbital

Contra Indications of Butalbital

Dosage of Butalbital

  • Strengths: 325 mg-50 mg; 650 mg-50 mg; 300 mg-50 mg; 325 mg-25 mg

Headache

Butalbital 50 mg/acetaminophen 300 or 325 mg

  • 1 or 2 tablets orally every 4 hours as needed not to exceed 6 tablets per day

Butalbital 25 mg/acetaminophen 325 mg

  • 2 tablets orally every 4 hours as needed not to exceed 12 tablets per day

Pediatric Dose for Headache

12 years or older
Butalbital 50 mg/acetaminophen 300 or 325 mg

  • 1 or 2 tablets orally every 4 hours as needed not to exceed 6 tablets per day
You Can Also Like   SSRIs (Selective Serotonin Reuptake Inhibitors)/SNRIs; Types

Butalbital 25 mg/acetaminophen 325 mg

  • 2 tablets orally every 4 hours as needed not to exceed 12 tablets per day

Side Effects of Butalbital

The most common

 Common

Rare/Less common

Drug Interactions of Butalbital

Butabital may interact with following drugs, supplements & may change the efficacy of the drug

You Can Also Like   Zafirlukast; Uses, Dosage, Side Effects, Drug Interactions

Pregnancy & Lactation

FDA Pregnancy Category C

Pregnancy

Medications used to prevent major seizures should not be stopped. The use of this medication is not recommended during pregnancy. However, the decision about whether or not to stop the medication must weigh the potential benefits against the potential risks. If you become pregnant while taking this medication, contact your doctor immediately.

Lactation

This medication passes into breast milk. If you are a breastfeeding mother and are taking phenobarbital, it may affect your baby. Talk to your doctor about whether you should continue breastfeeding.

References

 

Butalbital, Butalbital; Uses, Dosage, Side Effects, Interactions, Pregnancy, Rx Harun

Butalbital, Butalbital; Uses, Dosage, Side Effects, Interactions, Pregnancy, Rx Harun

Sharing to Spread to the World

Leave a Reply

Your email address will not be published.