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Mechanism of Action of Exemestane
Indications of Exemestane
- For the treatment of advanced breast cancer in postmenopausal women whose disease has progressed following tamoxifen therapy.
- Stage I Breast Carcinoma
- Refractory, advanced Breast cancer
- Breast cancer that is advanced.
- Breast cancer that is early stage and estrogen receptor positive.
- Exemestane is used in postmenopausal women who have already been treated with tamoxifen citrate. Exemestane is also being studied in the treatment of other types of cancer.
Therapeutic Uses of Exemestane
- Antineoplastic (hormonal).
- Exemestane is indicated for the treatment of advanced breast cancer in postmenopausal women whose disease has progressed following tamoxifen therapy.
- Use of exemestane in premenopausal women is not accepted.
Contra-Indications of Exemestane
- Vitamin D Deficiency
- Decreased Calcification or Density of Bone
- a mother who is producing milk and breastfeeding
Dosage of Exemestane
Strength: 25 mg
- 25 mg orally once a day
Side Effects of Exemestane
The most common
- abdominal or stomach pain
- burning, tingling, or prickly sensations
- decreased sense of touch
- a general feeling of tiredness or weakness
- Cough or hoarseness
- difficult or labored breathing
- fever or chills
- lower back or side pain
- mental depression
- swelling of the hands, ankles, feet, or lower legs
- tightness in the chest
- Chest pain
- difficult, burning, or painful urination
- frequent urge to urinate
- a headache
- a sore throat
- unexplained broken bones
- Abdominal or stomach pain
- clay-colored stools
- dark urine
- decreased urine output
- difficulty with speaking
- dilated neck veins
- double vision
- inability to move the arms, legs, or facial muscles
- inability to speak
- irregular breathing
- irregular heartbeat
- itching or rash
- loss of appetite
Drug Interactions of Exemestane
Exemestane may interact with following drugs, supplements & may change the efficacy of drugs
- St. John’s Wort
Pregnancy & Lactation
FDA pregnancy category – X
Although the effect of exemestane is unclear, there is some evidence suggesting that taking this medication during pregnancy may cause harm to an unborn baby. Exemestane should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.
It is not known if exemestane passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breastfeeding.