Famotidine; Uses, Dosage, Side effects, Drug Interactions

Famotidine








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Famotidine is a histamine H2 receptor antagonist that inhibits stomach acid production. It is a competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion. It is commonly used in the treatment of peptic ulcer disease and gastroesophageal reflux disease. Unlike cimetidine, the first H2 antagonist, famotidine has no effect on the cytochrome P450 enzyme system and does not appear to interact with other drugs.

Mechanism of Action of Famotidine

Famotidine binds competitively to H2-receptors located on the basolateral membrane of the parietal cell, blocking histamine effects. This competitive inhibition results in reduced basal and nocturnal gastric acid secretion and a reduction in gastric volume, acidity, and amount of gastric acid released in response to stimuli including food, caffeine, insulin, betazole, or pentagastrin.

Famotidine binds competitively to H2-receptors located on the basolateral membrane of the parietal cell, blocking histamine effects. This competitive inhibition results in reduced basal and nocturnal gastric acid secretion and a reduction in gastric volume, acidity, and amount of gastric acid released in response to stimuli including food, caffeine, H2-receptor antagonists inhibit basal and nocturnal gastric acid secretion by competitive inhibition of the action of histamine at the histamine H2-receptors of the parietal cells. They also inhibit gastric acid secretion stimulated by food, betazole, pentagastrin, caffeine, insulin, and physiological vagal reflex. /Histamine H2-receptor antagonists/

Indications of  Famotidine

Contra-Indications of Famotidine

Dosage of Famotidine

Strengths: 10 mg, 20 mg; 40 mg; 20 mg/50 mL; 40 mg/5 mL; 10 mg/mL;  20 mg/10 mL

Gastroesophageal Reflux Disease

Oral

  • Usual dose: 20 mg orally 2 times day
  • Duration of therapy: Up to 6 weeks

Parenteral

  • Usual dose: 20 mg IV every 12 hours

Duodenal Ulcer

Oral

  • Usual dose: 40 mg orally once a day at bedtime OR 20 mg orally 2 times a day
  • Maintenance dose: 20 mg orally once a day at bedtime
  • Duration of therapy: 4 weeks

Parenteral

  • Usual dose: 20 mg IV every 12 hours

Peptic Ulcer

Oral

  • Usual dose: 40 mg orally once a day at bedtime OR 20 mg orally 2 times a day
  • Maintenance dose: 20 mg orally once a day at bedtime
  • Duration of therapy: 4 weeks

Parenteral

  • Usual dose: 20 mg IV every 12 hours

Zollinger-Ellison Syndrome

Oral

  • Initial dose: 20 mg orally every 6 hours
  • Maximum dose: 160 mg orally every 6 hours

Parenteral

  • Usual dose: 20 mg IV every 6 to 12 hours

Dyspepsia

Oral, Over-the-Counter (OTC) Formulations

  • Treatment dose: 10 to 20 mg orally once
  • Symptom prevention: 10 to 20 mg orally once 10 to 60 minutes prior to consuming food/beverages that cause heartburn
  • Maximum dose: 2 tablets/day
  • The maximum duration of therapy: 14 days

Pediatric Peptic Ulcer

1 TO 16 years, Oral

  • Usual dose: 0.5 mg/kg orally once a day at bedtime OR 0.25 mg/kg orally 2 times a day
  • Maximum dose: 40 mg/day

Parenteral

  • Initial dose: 0.25 mg/kg IV injected over at least 2 minutes OR infused over 15 minutes every 12 hours
  • Maximum dose: 40 mg/day

16 years & older, Oral

  • Usual dose: 40 mg orally once a day at bedtime OR 20 mg orally 2 times a day
  • Maintenance dose: 20 mg orally once a day at bedtime
  • Duration of therapy: 4 weeks

Parenteral

  • Usual dose: 20 mg IV every 12 hours

Gastroesophageal Reflux Disease

Less than 3 months, Oral

  • Initial dose: 0.5 mg/kg orally once a day
  • Duration of therapy: Up to 8 weeks

3 month to less than 1 year, Oral

  • Initial dose: 0.5 mg/kg orally 2 times a day
  • Duration of therapy: Up to 8 weeks

1 Year to 16 Years, Oral

  • Usual dose: 0.5 mg/kg/day orally 2 times a day
  • Maximum dose: Up to 40 mg/dose

Parenteral

  • Initial dose: 0.25 mg/kg IV injected over at least 2 minutes OR infused over 15 minutes every 12 hours
  • Maximum dose: 40 mg/day

16 YEARS AND OLDER Oral

  • Usual dose: 20 mg orally 2 times day
  • Duration of therapy: Up to 6 weeks

Parenteral

  • Usual dose: 20 mg IV every 12 hours

Side Effects of Famotidine

The most common

More common

Rare

Drug Interactions

Famotidine may interact with following drugs, supplements, & may change the efficacy of drug

Pregnancy Catagory

FDA Pregnancy Category B

Pregnancy

The safety of this medication for use during pregnancy has not been established. This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Lactation

You should not take famotidine if you are breastfeeding. It may be excreted in your breast milk and may harm your nursing child.

References

Famotidine

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