Lomefloxacin; Uses, Dosage, Side Effects, Interactions









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Lomefloxacin is a synthetic broad-spectrum fluoroquinolone with antibacterial activity. Lomefloxacin inhibits DNA gyrase, a type II topoisomerase involved in the induction or relaxation of supercoiling during DNA replication. This inhibition leads to a decrease in DNA synthesis during bacterial replication, resulting in cell growth inhibition and eventually cell lysis.
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Lomefloxacin is only found in individuals that have used or taken this drug. It is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections. It is also used to prevent urinary tract infections prior to surgery. Lomefloxacin is a bactericidal fluoroquinolone agent with activity against a wide range of gram-negative and gram-positive organisms. The bactericidal action of lomefloxacin results from interference with the activity of the bacterial enzymes DNA gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase appears to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV appears to be the preferential target in gram-positive organisms. Interference with these two topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. As a result DNA replication and transcription is inhibited.

Mechanism of Action of Lomefloxacin

Lomefloxacin is a bactericidal fluoroquinolone agent with activity against a wide range of gram-negative and gram-positive organisms. The bactericidal action of lomefloxacin results from interference with the activity of the bacterial enzymes DNA gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase appears to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV appears to be the preferential target in gram-positive organisms. Interference with these two topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. As a result DNA replication and transcription is inhibited.

Indications of Lomefloxacin

  •  For the treatment of bacterial infections of the respiratory tract (chronic bronchitis) and urinary tract, and as a pre-operative prophylactic to prevent urinary tract infection caused by S.pneumoniaeH.influenzaeS.aureusP.aeruginosaE. cloacaeP. mirabilisC. civersusS. asprphyticusE.coli, and K.pneumoniae.
  • Bronchitis
  • Escherichia coli Infections
  • Klebsiella Infections
  • Proteus Infections
  • Pseudomonas Infections
  • Staphylococcal Infections
  • Streptococcal Infections
  • Urinary Tract Infections
  • Bladder Infection
  • Prostatitis
  • Salmonella Enteric Fever
  • Salmonella Gastroenteritis
  • Shigellosis
  • Transurethral Prostatectomy
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Contra-Indications of Lomefloxacin

  • Clostridium difficile infection
  • Low amount of magnesium in the blood
  • Low amount of potassium in the blood
  • Peripheral neuropathy
  • Very Rapid Heartbeat – Torsades de Pointes
  • prolonged QT interval on EKG
  • Abnormal EKG with QT changes from Birth
  • Severe renal impairment
  • Drug or Chemical-Induced Sensitivity to Sunlight
  • Inflammation of the Tendon
  • Rupture of a Tendon
  • Seizures
  • A mother who is producing milk and breastfeeding
  • Allergies to Quinolones

Side Effects of Lomefloxacin

The most common 

More common

Rare

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Dosage of Lomefloxacin

  • Strengths: 400 mg

Bronchitis

  • 400 mg orally once a day for 10 days

Cystitis

  • 400 mg orally once a day for 3 days
  • Duration: 3 days if caused by E coli in females; 10 days if caused by K pneumoniae, P mirabilis, or S saprophyticus

Prostatitis

  • 400 mg orally once a day for 14 to 30 days

Salmonella Enteric Fever

  • 400 mg orally once a day for 7 to 14 days

Salmonella Gastroenteritis

  • 400 mg orally once a day for 3 days

Shigellosis

  • 400 mg orally once a day for 3 to 5 days

Transurethral Prostatectomy

  • 400 mg orally 2 to 6 hours prior to the procedure

Urinary Tract Infection

  • Complicated: 400 mg orally once a day for 14 days

Drug Interactions of Lomefloxacin

Lomefloxacin may interact with following drugs, supplements, & may change the efficacy of drugs

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Pregnancy and Lactation of Lomefloxacin

FDA Pregnancy  Risk Category C

Pregnancy 

In animal studies, pregnant animals were given this medication and had some babies born with problems. No well-controlled studies have been done in humans, though. Therefore, this medication may be used if the potential benefits to the mother outweigh the potential risks to the unborn child.

Lactation

There are no well-controlled studies that have been done in pregnant women. Lomefloxacin should be used during pregnancy only if the possible benefit outweighs the possible risk to the unborn baby.

References

Lomefloxacin

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