Nitrazepam; Uses, Dosage, Side Effects, Interactions

Nitrazepam
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Nitrazepam is only found in individuals that have used or taken this drug. It is a benzodiazepine derivative used as an anticonvulsant and hypnotic. Nitrazepam belongs to a group of medicines called benzodiazepines. It acts on benzodiazepine receptors in the brain which are associated with the GABA receptors causing an enhanced binding of GABA (gamma amino butyric acid) to GABAA receptors. GABA is a major inhibitory neurotransmitter in the brain, involved in inducing sleepiness, muscular relaxation, and control of anxiety and fits, and slows down the central nervous system. The anticonvulsant properties of nitrazepam and other benzodiazepines may be in part or entirely due to binding to voltage-dependent sodium channels rather than benzodiazepine receptors. Sustained repetitive firing seems to be limited by benzodiazepines effect of slowing recovery of sodium channels from inactivation.

Nitrazepam is a type of benzodiazepine drug. It is a powerful hypnotic drug which possesses strong sedative, anxiolytic, amnestic, anticonvulsant, and skeletal muscle relaxant properties. Nitrazepam shortens the time required to fall asleep and lengthens the duration of sleep. It is also useful for the management of myoclonic seizures.

Mechanism of action of Nitrazepam 

Nitrazepam belongs to a group of medicines called benzodiazepines. It acts on benzodiazepine receptors in the brain which are associated with the GABA receptors causing an enhanced binding of GABA (gamma amino butyric acid) to GABAA receptors. GABA is a major inhibitory neurotransmitter in the brain, involved in inducing sleepiness, muscular relaxation and control of anxiety and fits, and slows down the central nervous system. The anticonvulsant properties of nitrazepam and other benzodiazepines may be in part or entirely due to binding to voltage-dependent sodium channels rather than benzodiazepine receptors. Sustained repetitive firing seems to be limited by benzodiazepines effect of slowing recovery of sodium channels from inactivation.

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Indications of Nitrazepam 

Contra-Indications of Nitrazepam 

Dosages of Nitrazepam 

Strength: 5mg; 10 mg; 25mg

Adults

  • 5mg before going to bed, your doctor may increase this up to 10mg.

Elderly and debilitated patients

  • 2.5-5mg before going to bed. It is particularly important to take this medicine exactly as directed by the doctor.

Infantile spasms

  • Child: Infants: 125 mcg/kg bid; gradually increase to 250-500 mcg/kg bid.

Children under 12 years: Not recommended.

Side Effects of Nitrazepam 

The most common

Common

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Serious

Drug Interactions of Nitrazepam 

Nitrazepam may interact with following drugs, Supplements & may change the efficacy of drugs

Pregnancy & Lactation of Nitrazepam 

FDA Pregnancy Category D

Pregnancy

Nitrazepam, like other benzodiazepines, can cause harm to an unborn baby if the mother takes it while pregnant. This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Lactation

This medication passes into breast milk. If you are a breastfeeding mother and are taking nitrazepam, it may affect your baby. Talk to your doctor about whether you should continue breastfeeding. The safety and effectiveness of nitrazepam for sleep difficulties have not been established for children and adolescents less than 18 years of age.

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References

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