Pindolol; Indications/Uses, Dosage, Side Effects, Interactions ,Pregnancy

Pindolol








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Pindolol is an aryloxypropanolamine derivative with the antihypertensive property. Pindolol competitively binds to beta-adrenergic receptors, resulting in a decrease in beta-adrenergic activities, i.e., vasodilation, and negative chronotropic and inotropic effects. In addition, this agent blocks serotonin (5-HT) 1A receptors, thereby increasing the available serotonin in the brain. Increased serotonin levels augment the antidepressant action of selective serotonin reuptake inhibitors and monoamine oxidase inhibitors.

Pindolol is a nonselective beta-adrenergic receptor blocker that is widely used for the therapy of hypertension and angina pectoris. Pindolol has yet to be convincingly associated with clinically apparent liver injury.

Mechanism of Action of Pindolol

Pindolol non-selectively blocks beta-1 adrenergic receptors mainly in the heart, inhibiting the effects of epinephrine and norepinephrine resulting in a decrease in heart rate and blood pressure. By binding beta-2 receptors in the juxtaglomerular apparatus, Pindolol inhibits the production of renin, thereby inhibiting angiotensin II and aldosterone production and therefore inhibits the vasoconstriction and water retention due to angiotensin II and aldosterone, respectively.

A moderately lipophilic beta blocker (adrenergic beta-antagonists). It is non-cardioselective and has intrinsic sympathomimetic actions, but little membrane-stabilizing activity. It is also an antagonist of the serotonin 5-HT1A receptor, preferentially blocking inhibitory 5-HT1A autoreceptors, and has been researched as an add-on therapy to selective serotonin reuptake inhibitors (SSRIs) in the treatment of depression, though with little or no effectiveness ultimately seen.

Indications of Pindolol

Contra-Indications of Pindolol

Dosage of Pindolol

Strengths: 5 mg; 10 mg;

Hypertension

  • Initial dose: 5 mg orally 2 times a day
  • Titration: The dose may be adjusted in increments of 10 mg per day every 3 to 4 weeks
  • Maximum dose: 60 mg per day

Side Effects of Pindolol

The most common

More common

Rare

Drug Interactions of 

Pindolol may interact with the the following drug, supplements, & may change the efficacy of the drug

Pregnancy Catagory of Pindolol

FDA Pregnancy Category C

Pregnancy

The safety of this medication for use by pregnant women has not been established. It should not be taken by pregnant women unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Lactation

Pindolol passes into breast milk.  If you are a breastfeeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breastfeeding. The safety and effectiveness of using this medication have not been established for children.

References

Pindolol

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