Risedronic Acid; Uses, Side Effects, Interactions, Pragnancy

Risedronic acid, Risedronic Acid; Uses, Side Effects, Interactions, Pragnancy, Rx Harun
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Risedronic acid is a Bisphosphonate. The chemical classification of risedronic acid is Diphosphonates. Risedronate Sodium is the sodium salt of the risedronic acid, a synthetic pyridinyl bisphosphonate. Risedronic acid binds to hydroxyapatite crystals in bone and inhibits osteoclast-dependent bone resorption.

Risedronic acid often used as its sodium salt risedronate sodium (USAN) is a bisphosphonate used to strengthen bone, treat osteoporosis caused by menopause, steroid use, or gonadal failure. This medicine is for use when you have a high risk of bone fracture due to osteoporosis or prevent osteoporosis, and treat Paget’s disease of bone.

Risedronate is a pyridinyl bisphosphonate that inhibits osteoclast-mediated bone resorption and modulates bone metabolism and is indicated for the treatment and prevention of osteoporosis in postmenopausal women.

Mechanism of Action of Risedronic acid 

The action of risedronate on bone tissue is based partly on its affinity for hydroxyapatite, which is part of the mineral matrix of bone. Risedronate also targets farnesyl pyrophosphate (FPP) synthase. Nitrogen-containing bisphosphonates (such as pamidronate, alendronate, risedronate, ibandronate, and zoledronate) appear to act as analogs of isoprenoid diphosphate lipids, thereby inhibiting FPP synthase, an enzyme in the mevalonate pathway. Inhibition of this enzyme in osteoclasts prevents the biosynthesis of isoprenoid lipids (FPP and GGPP) that are essential for the post-translational farnesylation and geranylgeranylation of small GTPase signaling proteins. This activity inhibits osteoclast activity and reduces bone resorption and turnover. In postmenopausal women, it reduces the elevated rate of bone turnover, leading to, on average, a net gain in bone mass.

Indications of Risedronic acid 

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Contra-Indications of Risedronic acid 

The dosage of Risedronic acid 

Strengths:  5 mg; 30 mg; 35 mg;  75 mg; 150 mg;

Treatment Of Postmenopausal Osteoporosis

The recommended regimen is:

  • one 5 mg tablet orally, taken daily
    or
  • one 35 mg tablet orally, taken once-a-week
    or
  • one 75 mg tablet orally, taken on two consecutive days for a total of two tablets each month
    or
  • one 150 mg tablet orally, taken once-a-month

Prevention Of Postmenopausal Osteoporosis

The recommended regimen is

  • one 5 mg tablet orally, taken daily
    or
  • one 35 mg tablet orally, taken once-a-week
    or
  • alternatively, one 75 mg tablet orally, taken on two consecutive days for a total of two tablets each month may be considered
    or
  • alternatively, one 150 mg tablet orally, taken once-a-month may be considered
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Treatment To Increase Bone Mass In Men With Osteoporosis

The recommended regimen is

  • one 35 mg tablet orally, taken once-a-week

Treatment And Prevention Of Glucocorticoid-Induced Osteoporosis

The recommended regimen is

  • one 5 mg tablet orally, taken daily

Paget’s Disease

-30 mg orally once a day for 2 months

Side Effects of Risedronic acid 

The most common 

Common

Rare

Drug Interactions Risedronic acid 

The risedronic acid may interact with following drugs, supplements & may change the efficacy of drugs

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If you must take these medicines, wait at least 30 minutes after taking risedronate.

Pregnancy & Lactation of Risedronic acid 

FDA pregnancy category C

Pregnancy

Risedronate is not intended for use during pregnancy. If you become pregnant while taking this medication, contact your doctor immediately.

Lactations

It is not known if risedronate passes into breast milk. If you breastfeeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding. The safety and effectiveness of using this medication have not been established for children.

References

Risedronic acid, Risedronic Acid; Uses, Side Effects, Interactions, Pragnancy, Rx Harun

Risedronic acid, Risedronic Acid; Uses, Side Effects, Interactions, Pragnancy, Rx Harun

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