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Glucosamine, Diacerein is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies. It is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Since glucosamine is a precursor for glycosaminoglycans, and glycosaminoglycans are a major component of joint cartilage, supplemental glucosamine may help to rebuild cartilage and treat arthritis.
Glucosamine is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Glucosamine is part of the structure of the polysaccharides chitosan and chitin, which compose the exoskeletons of crustaceans and other arthropods, as well as the cell walls of fungi and many higher organisms. Glucosamine is one of the most abundant monosaccharides. It is produced commercially by the hydrolysis of crustacean exoskeletons or, less commonly, by fermentation of a grain such as corn or wheat. It is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Since glucosamine is a precursor for glycosaminoglycans, and glycosaminoglycans are a major component of joint cartilage, supplemental glucosamine may help to rebuild cartilage and treat arthritis.
Mechanism of Action of Glucosamine
Glucosamine is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Oral glucosamine is commonly used for the treatment of osteoarthritis. Since glucosamine is a precursor for glycosaminoglycans, and glycosaminoglycans are a major component of joint cartilage, supplemental glucosamine may help to rebuild cartilage and treat arthritis. Its use as a therapy for osteoarthritis appears safe, but there is conflicting evidence as to its effectiveness with more recent studies showing limited to no clinical benefit of use. In the United States, glucosamine is not approved by the Food and Drug Administration for medical use in humans. Since glucosamine is classified as a dietary supplement, safety and formulation are solely the responsibility of the manufacturer; evidence of safety and efficacy is not required as long as it is not advertised as a treatment for a medical condition.
When taken up by living cells, glucosamine reacts with ATP to form glucosamine-6-phosphate, the natural precursor of glycosaminoglycans (GAGs) that contain N-acetylglucosamine (keratan sulfate and Hyaluronan) and those that have N-acetylgalactosamine (heparan sulfate and chondroitin sulfate). These GAGs are polysaccharides composed of hexosamines and monosaccharides (e.g., galactose and glucuronic acid) arranged as a linear chain of repeating disaccharide units (such as the glucuronic acid and N-acetylgalactosamine-6-sulfate of chondroitin sulfate). With the exception of hyaluronan, GAGs do not exist alone in nature but are attached to specific “core” proteins, and the composite structures are called proteoglycans (protein-glycosaminoglycans). Both hyaluronan and many different kinds of proteoglycans (such as aggrecan, versican, and syndecan) are abundant throughout the body where they perform diverse functions.
Indications of Glucosamine
- Osteoarthritis of Knee & Spine
- Cervical spondylosis
- Back pain
- Weight loss
- Degeneration of cartilage
- Road Traffic accident,
- Post operative joint injury
- Joints pain
- Joint pain, such as knee pain
- Multiple sclerosis (MS)
- Glucosamine may be indicated for the treatment and prevention of osteoarthritis, either by itself or in combination with chondroitin sulfate.
Side Effects of Glucosamine
Drug Interactions Glucosamine
Ask your doctor about whether glucosamine is safe for you if you’re taking any of the following:
- Non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen and naproxen
- Drugs that stop platelets from sticking together, such as clopidogrel
- Blood thinners, such as warfarin , heparin, apixaban , rivaroxaban , and fondaparinux
- Medications for depression like citalopram and venlafaxine
- Cancer chemotherapy drugs, such as etoposide and doxorubicin
- Diabetes medications, such as pioglitazone , rosiglitazone , and insulin
Pregnancy & Lactation of Glucosamine
Glucosamine is an amino-monosaccharide that is either derived from shellfish or synthetically produced. Glucosamine sulfate has no specific lactation-related uses. It is most commonly used to treat osteoarthritis. A glucosamine derivative, N-acetylglucosamine, is a normal component of human breastmilk. Glucosamine sulfate is well tolerated with occasional gastrointestinal discomfort (e.g., diarrhea, heartburn, nausea, vomiting) reported.
Does glucosamine help with osteoarthritis?
Many people take glucosamine supplements for OA, and especially OA of the hip or knee.
Some studies suggest that glucosamine may have the following effects:
- Reduce osteoarthritis-related pain, stiffness, and swelling in the joints.
- Improve function in people with knee or hip osteoarthritis.
- Provide continued relief of symptoms for up to 3 months after someone stops treatment.
In advance formula that are very helpful in combination of Diacerein
Uses of Diacerein 50mg + Glucosamine 750mg
Glucosamine help in building cartilge, tendon and tendon around the bones & joint. Thereby It enhances joint lubrication , cushioning of joints and elevates pain around joints. It is used along with other medicines like chondrotin or diacerin for better joint cushioning and lubrication. Its uses include treatment of pain associated with osteoarthritis or other joint pains related to cartilage damage.
Side Effects of Diacerein 50mg + Glucosamine 750mg:
Intense Yellow Colouring Of Urine.
intense yellow coloring of urine
Drug Interactions of Diacerein 50mg + Glucosamine 750mg:
Decrease the absorbation of aluminium ormagnesium hcl, Antacids. Increase the risk Diarrhoea with laxatives, antibiotic
Contraindications of Diacerein 50mg + Glucosamine 750mg:
Pregnancy, Lactation. hypersensitivity ho anthraquinone derivatives