Umeclidinium Bromide ; Defination, Mechanism, Indications, Contra indications,Dosage, Side effects, Drug Interaction ,Pregnancy Catagory

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Umeclidinium bromide is a long-acting muscarinic antagonist approved for the maintenance treatment of chronic obstructive pulmonary disease (COPD).It is also approved for this indication in combination with vilanterol

Mechanism of action

Umeclidinium is a long-acting, antimuscarinic agent, which is often referred to as an anticholinergic. It has similar affinity to the subtypes of muscarinic receptors M1 to M5. In the airways, it exhibits pharmacological effects through the inhibition of M3 receptor at the smooth muscle leading to bronchodilation.

Indications 

Contra Indications

Dosage

Strengths: 62.5 mcg (0.0625 mg)/inh

Chronic Obstructive Pulmonary Disease – Maintenance

  • 1 inhalation (62.5 mcg) orally once a day
  • Maximum dose: 1 inhalation every 24 hours

Side Effects

The most common

More common

Rare

Drug Interactions

Umeclidinium bromide  may interact with following drugs,suppliment & may change the efficacy of drugs

Pregnancy Catagory

FDA Pregnancy Category C

Pregnancy

Umeclidinium falls into category C. In animal studies, pregnant animals were given this medication and there was no evidence of problems for the mother or offspring. No well-controlled studies have been done in humans. Therefore, this medication may be used if the potential benefits to the mother outweigh the potential risks to the unborn child.

Lactation

It is not known if umeclidinium crosses into human milk. Because many medications can cross into human milk and because of the possibility for serious adverse reactions in nursing infants with use of this medication, a choice should be made whether to stop nursing or stop the use of this medication.

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